The new boat is more than twice the size of previous one and has about 4,400 gambling positions, which Pennsylvania-based owner Penn National Gaming Inc. says is the most of any riverboat casino in the country.
The casino is less than two miles from a bridge to Cincinnati's Kentucky suburbs and has been under construction for two years.
The Lawrenceburg casino and the Horseshoe Casino along Lake Michigan in Hammond have been Indiana's busiest riverboats.